Thrayir, Eyes of the Siren

Reach Siren Isle by taking the Zeppelin in Dornogal at 72, 5, or using the Mole Machine in the Ringing Deeps at 46, 30. Once on the island, speak to Suzie Boltwrench at 69, 49 to enter the storm phase, which is required to obtain all five Runekeys.

Enter the Forgotten Vault cave entrance at 44, 23 on Siren Isle, run down the corridor to the last room, and defeat Ksvir the Forgotten at 38, 76 to loot the Whirling Runekey — this appears to be a guaranteed drop during the storm.

Collect 7 Torrential Fragments by killing any mobs on Siren Isle during the storm — including normal mobs, elites, and rares — then combine them to create the Torrential Runekey.

Collect 5 Thunderous Fragments from treasure chests inside the storm — Runed Storm Caches can be found at multiple locations including 31, 72.4, 37.9, 38.8, 39.6, 66.8, 49.7, 75.8, 53, 40.7, 53.8, 75.6, 60.8, 62.3, 68.3, 73.6, 38.9, 20.2, 39.1, 40.7, and 40, 52.1 — then combine them to create the Thunderous Runekey.

Once you have all five Runekeys — including the Cyclonic Runekey and Turbulent Runekey — head into the Forgotten Vault and use each key on its corresponding Runestone surrounding Thrayir at 72.7, 61.32. Your progress saves between sessions, so you can activate each stone as you collect its key.