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Nemesis: Manslayer
Complete the quest Nemesis: Manslayer at the Gladiator's Sanctum.
Nemesis: Manslayer requires you to kill 500 Human players in PvP combat across Draenor, then complete the associated quest at the Gladiator's Sanctum to earn the title 'the Manslayer'.
Build the Gladiator's Sanctum
The quest to turn in your 500 kills is completed at the Gladiator's Sanctum, so have that building active in your garrison.
Kill 500 Human Players
Only PvP kills of Human players made in Draenor zones or Ashran count toward this quest's progress — kills outside of Draenor do not credit.
Group Up to Multiply Credits
If you form a group of up to 5 players who all have the Nemesis: Manslayer quest active, each enemy Human player killed grants a kill credit to every member of the group, effectively multiplying your progress by the group size.
Claim the Manslayer Title
After reaching 500 kills, turn in the quest at the Gladiator's Sanctum; the title is listed as 'the Manslayer' in your title list, so it will display as 'Your Name the Manslayer'.
Tips
Stacking 5 players who all have the quest active means a single kill counts as 5 credits for each person, reducing the effective grind from 500 kills to as few as 100 coordinated kills.