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Silas' Sphere of Transmutation
Craft Silas' Sphere of Transmutation, the Tool of the Trade for Alchemy.
Craft 
Silas' Sphere of Transmutation, the Tool of the Trade for Alchemy introduced in Battle for Azeroth, by completing a quest chain and gathering dungeon drops to unlock and craft the recipe.
Reach 150 Alchemy Skill
You must have 150 skill points in Kul Tiran or Zandalari Alchemy before you can craft Silas' Sphere of Transmutation.
Obtain the Recipe
Complete the Alchemy Tool of the Trade quest chain for your faction. If the quest does not appear after releveling Alchemy, open the Alchemy trainer's inventory directly — the recipe can be purchased from them there.
Farm Waycrest Manor
Enter Waycrest Manor on any difficulty and defeat Thistle Acolyte to collect 
Purposefully Potent Potion.
Farm Atal'Dazar
Enter Atal'Dazar on any difficulty and defeat Priestess Alun'za to collect 
Sphere of Sangaurum.
Farm The MOTHERLODE!!
Enter The MOTHERLODE!! on any difficulty and defeat Venture Co. Mastermind or Venture Co. Alchemist to collect 
Extremely Precise Vial.
Farm Tol Dagor
Enter Tol Dagor on any difficulty and defeat Jes Howlis to collect 
Sly Rogue's Decanter.
Gather Remaining Materials
Purchase 50 
Anchor Weed from the Auction House, and obtain 1 
Mystical Cauldron.
Craft the Sphere
With all materials in your bags and the recipe learned, craft Silas' Sphere of Transmutation at your Alchemy crafting station to complete the achievement.
Tips
Each dungeon boss can be run on any difficulty, so enter on Normal to clear quickly and reset the lockout for additional attempts if a drop is missed.